Long non-coding RNA FAM83H-AS1 acts as a potential oncogenic driver in human ovarian cancer

Abstract Objective Ovarian cancer (OC) is one of the most aggressive women cancers with increasing incidence and mortality rates worldwide. Long non-coding RNAs (lncRNAs) could as major players in OC process. Although FAM83H antisense RNA1 (FAM83H-AS1) demonstrated play an important roles a many cancers, detailed function mechanism has not been reported OC. Results We integrated multiple kinds bioinformatics approaches experiments validated method to evaluate functions FAM83H-AS1 Some differential expressed lncRNAs were identified between normal control tissues. was differentially up-regulated types. Specially, expression higher showed difference diverse stages. High associated worse pan-cancer outcomes. FAM83H-AS1-centric network including lncRNA-miRNA, lncRNA-protein lncRNA-mRNA ceRNA constructed infer FAM83H-AS1. There two methylation sites cg01399317 cg20519035 located at The level correlated gene infiltration immune cell macrophage, neutrphil dendritic patients. Lastly, qRT-PCR that tissues than Conclusion Collectively, these results indicated may act oncogenic driver it be potential therapy target